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Proper Care and Cleaning of the Microscope

Proper Care and Cleaning of the Microscope

Published on: August 11, 2008

Microscopic polyangiitis with dermatomyositis.

Erin M Bauer^1,2, Ernest Brahn¹

¹Department of Rheumatology, University of California, David Geffen School of Medicine, Los Angeles, California, USA.

European Journal of Rheumatology

|January 9, 2018

Summary

This summary is machine-generated.

This case study highlights a rare instance of dermatomyositis co-occurring with microscopic polyangiitis. Prompt evaluation of positive p-ANCA and renal insufficiency is crucial in dermatomyositis patients.

Keywords:

ANCA associated vasculitis Dermatomyositis microscopic polyangiitis renal failure

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Area of Science:

Rheumatology
Nephrology
Autoimmune Diseases

Background:

Dermatomyositis is a rare autoimmune disorder characterized by muscle weakness and skin rashes.
Extramuscular manifestations are common, but renal involvement is atypical.
Microscopic polyangiitis is a rare autoimmune vasculitis that can affect the kidneys.

Purpose of the Study:

To report a unique case of concomitant dermatomyositis and microscopic polyangiitis.
To emphasize the importance of evaluating renal function and specific autoantibodies in dermatomyositis patients.

Main Methods:

Case report of a 62-year-old female with dermatomyositis symptoms.
Serologic evaluation including p-ANCA testing.
Renal biopsy to diagnose microscopic polyangiitis.
Treatment with cyclophosphamide and rituximab.

Main Results:

Patient presented with classic dermatomyositis symptoms but normal creatine kinase levels.
Positive p-ANCA was detected initially.
Renal biopsy confirmed microscopic polyangiitis, leading to renal insufficiency.
The patient achieved sustained remission for over 2 years with treatment.

Conclusions:

Dermatomyositis and microscopic polyangiitis can co-occur, despite their individual rarity.
Positive p-ANCA and developing renal insufficiency warrant urgent investigation in dermatomyositis patients.
This case underscores the need for comprehensive evaluation in complex autoimmune presentations.