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Relationship Between Adiponectin and apoB in Individuals With Diabetes in the Atlantic PATH Cohort

Vanessa DeClercq1, Yunsong Cui1, Trevor J B Dummer2

  • 1Population Cancer Research Program, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.

Journal of the Endocrine Society
|January 9, 2018
PubMed

Insights

Diabetes and obesity increase cardiovascular risk. This study found lower adiponectin in people with diabetes, especially women, but similar cardiovascular risk markers when matched for adiposity.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Syndrome

Background:

  • Obesity and diabetes are rising, increasing cardiovascular disease (CVD) risk.
  • The complex interplay between diabetes, obesity, and CVD requires further biological understanding.

Purpose of the Study:

  • To investigate the relationship between adiponectin (adipose tissue function marker) and apolipoprotein B (apoB, a CVD risk marker).
  • To compare these markers in participants with and without diabetes, matched for body mass index (BMI).

Main Methods:

  • A nested case-control study within the Atlantic Partnership for Tomorrow's Health (PATH) cohort.
  • 480 participants (35-69 years), 240 with and 240 without diabetes, matched for sex and BMI.
  • Plasma adiponectin and apoB levels were measured using immunoassays.

Main Results:

  • Plasma adiponectin was lower in participants with diabetes compared to those without, particularly in women.
  • Apolipoprotein B levels were similar between diabetic and non-diabetic participants when matched for sex and adiposity.
  • Participants with diabetes had higher measures of adiposity.

Conclusions:

  • Adiposity measures were higher in the diabetes group.
  • Adiponectin showed a strong inverse association with diabetes when participants were matched for adiposity.
  • These findings highlight adiponectin's role in the diabetes-cardiovascular link, particularly in women.
Abstract

Keywords:
adiponectinapolipoprotein Bdiabetesobesity

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