[Antimicrobial effect of a new bio-ceramic material iRoot FM on Porphyromonas endodontalis]

To compare the antimicrobial effect of a new bio-ceramic material iRoot FM with traditional intracanal medicaments including calcium hydroxide [Ca(OH)₂] and triple antibiotic paste (TAP), on Porphyromonas endodontalis (P. endodontalis), and to evaluate the antimicrobial activity of iRoot FM, providing reference for clinical use of intracanal medicaments.

P. endodontalis ATCC 35406 were used in this study. The study was divided into 3 experimental groups including iRoot FM, Ca(OH)₂ and TAP group. Sterile water was used as blank control. Frozen P. endodontalis were seeded and grown overnight in the liquid medium, then P. endodontalis were seeded on BHI-blood agar plates. After the plates were dried, the materials were filled on the plates which were made by a punching machine. Zones of inhibition (mm) were measured after 72 h of anaerobic incubation at 37degrees centigrade. The experimental data were analyzed statistically using SPSS 17.0 software package.

The zones of inhibition in the 3 experimental groups: iRoot FM, Ca(OH)₂ and TAP group were (20.74±4.35)mm, (24.89±3.84)mm and (34.51±1.20)mm, respectively. The zones of inhibition of the iRoot FM group and Ca(OH)₂ group were significantly smaller compared with the TAP group (P<0.05), while there was no significant difference between the iRoot FM group and Ca(OH)2 groups (P>0.05). There were no zone of inhibition in the control group.

As a new bio-ceramic material, iRoot FM shows a good antimicrobial activity against P. endodontalis and may be a promising intracanal material.