Related Experiment Video

Updated: Feb 16, 2026

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
08:55

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag

Published on: December 14, 2017

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The LRRK2 signalling system

Alice Price1, Claudia Manzoni1,2, Mark R Cookson3

  • 1School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6AP, UK.

Cell and Tissue Research
|January 9, 2018
PubMed

Insights

Leucine-rich repeat kinase 2 (LRRK2) is key to Parkinson's disease genetics. This review explores LRRK2's complex cellular roles to clarify how its mutations contribute to Parkinson's disease pathogenesis.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • The leucine-rich repeat kinase 2 (LRRK2) gene is a significant genetic risk factor for Parkinson's disease.
  • LRRK2 protein is a multi-domain enzyme involved in various cellular signaling pathways.
  • Understanding LRRK2's function is crucial for Parkinson's disease research due to its complex role.

Purpose of the Study:

  • To review the systems-level events involving LRRK2.
  • To clarify how LRRK2 mutations and variants contribute to Parkinson's disease.
  • To provide a comprehensive understanding of LRRK2 biology and pathobiology.

Main Methods:

  • Literature review of studies on LRRK2.
  • Analysis of signaling pathways associated with LRRK2.
  • Systems-level investigation of LRRK2's cellular functions.

Main Results:

  • LRRK2 participates in diverse cellular signaling networks.
  • The complexity of LRRK2 pathways has hindered understanding of disease-associated variants.
  • A systems-level perspective is essential for deciphering LRRK2's role in Parkinson's disease.

Conclusions:

  • A systems-level understanding of LRRK2 is critical for advancing Parkinson's disease research.
  • Further investigation into LRRK2's complex signaling is needed to elucidate its pathobiology.
  • Clarifying LRRK2's role may lead to novel therapeutic strategies for Parkinson's disease.
Keywords:
KinaseLRRK2Parkinson’s diseaseROCO proteinSignal transduction

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