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Association of ANRIL Expression with Coronary Artery Disease in Type 2 Diabetic Patients

Esmaeil Rahimi1, Amirhossein Ahmadi1, Mohammad Ali Boroumand2

  • 1Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Cell Journal
|January 9, 2018
PubMed
Abstract

Insights

Antisense noncoding RNA in INK4 locus (ANRIL) expression is elevated in type 2 diabetes mellitus (T2DM) patients with coronary artery disease (CAD). ANRIL may serve as a biomarker for detecting CAD in diabetic individuals.

Area of Science:

  • Genetics and Molecular Biology
  • Cardiovascular Disease Research
  • Endocrinology and Metabolism

Background:

  • The INK4 locus harbors the ANRIL gene, a key player in various diseases including coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).
  • ANRIL expression is frequently altered in immune-mediated conditions, and CAD significantly impacts T2DM patient mortality.
  • Understanding ANRIL's role in T2DM patients with CAD is crucial for identifying potential diagnostic markers.

Purpose of the Study:

  • To investigate and compare ANRIL gene expression levels in T2DM patients, differentiating between those with and without CAD.
  • To evaluate ANRIL as a potential biomarker for CAD in the context of type 2 diabetes.

Main Methods:

  • A case-control study design was employed.
  • ANRIL expression was quantified using quantitative reverse transcription-polymerase chain reaction (RT-qPCR) in peripheral blood mononuclear cells.
  • The study included 64 T2DM patients, categorized into CAD-positive (n=33) and CAD-negative (n=31) groups based on coronary angiography.

Main Results:

  • ANRIL expression was significantly upregulated (2.34-fold, P=0.012) in T2DM patients with CAD compared to those without CAD.
  • Receiver operating characteristic (ROC) curve analysis indicated that ANRIL has potential as a biomarker for CAD detection in diabetic patients.

Conclusions:

  • Elevated ANRIL expression levels are associated with the presence of CAD in patients with type 2 diabetes mellitus.
  • ANRIL demonstrates potential as a peripheral biomarker for identifying coronary artery disease in diabetic individuals.
Keywords:
ANRILCoronary Artery DiseaseGene ExpressionNoncoding RNAType 2 Diabetes Mellitus

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