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Updated: Feb 16, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
[Roles of macrophage-mediated epithelial mesenchymal transdifferentiation in fibrotic diseases]
Qianqian Zhang1, Xiaohui Zhou, Lunxian Tang
1Tongji University School of Medicine, Shanghai 200120, China (Zhang QQ); Translational Medicine Research Center, East Hospital, Tongji University, Shanghai Institute of Heart Failure, Shanghai 200120, China (Zhou XH); Department of Emergency Medicine and Critical Care, East Hospital, Tongji University, Shanghai 200120, China (Tang LX). Corresponding author: Tang Lunxian,
Objective:
It is reported that fibrotic changes seemed to be associated with poor prognosis in patients with organ dysfunction, unfortunately no effective treatment existed currently. Recent studies have demonstrated that macrophages can interact with epithelial cells to induce epithelial mesenchymal transdifferentiation (EMT) which is thought to play a key role in the pathogenesis of a variety of fibrotic diseases. Therefore, this review will summarize the potential role of macrophages in the molecular mechanisms of EMT-associated fibrosis. We aimed to provide a possible therapeutic approaches for the fibrotic diseases.
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