Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels
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Updated: Feb 16, 2026

Four-Dimensional Printing of Stimuli-Responsive Hydrogel-Based Soft Robots
Published on: January 13, 2023
Tongbing Sun1, Caizhen Zhu2, Jian Xu3
1College of Chemical and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong Province, China. czzhu@szu.edu.cn and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, Beijing, China. jxu@iccas.ac.cn.
Abstract:
Novel biodegradable diselenide cross-linked starch-based hydrogels were synthesized via free radical copolymerization, which serve as stimuli-responsive drug release materials composed of starch chain backbones with an enzyme hydrolysis property and selenium-containing cross-linkers with a redox responsive cleavage property. Rhodamine B (RB) loaded starch-based hydrogels were prepared in order to investigate their stimuli-responsive release behaviours. In the presence of external redox agents, the enzyme stimuli as well as the mixture of the above stimuli, the prepared starch-based hydrogels exhibit controlled multi-responsive release behavior of RB. Overall, the merits of good biodegradation and multi-stimuli responsiveness make these kinds of starch-based hydrogels promising biomedical candidates for the realization of controlled drug delivery.
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