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Related Experiment Video

Updated: Feb 16, 2026

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

A Pre-clinical Rat Model for the Study of Ischemia-reperfusion Injury in Reconstructive Microsurgery

Published on: November 8, 2019

Microbeam evolution: from single cell irradiation to pre-clinical studies.

Mihaela Ghita¹, Cristian Fernandez-Palomo², Hisanori Fukunaga¹

¹a Centre for Cancer Research and Cell Biology , Queen's University Belfast , Belfast , UK.

International Journal of Radiation Biology

|January 9, 2018

Summary

Radiation microbeam technology has evolved from single cell studies to in vivo treatments. This review highlights microbeam applications, focusing on pre-clinical research and translation to clinical Microbeam Radiotherapy (MRT).

Keywords:

DNA damage MRT Microbeam bystander effects of radiation

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Area of Science:

Radiobiology
Medical Physics
Radiation Oncology

Background:

Microbeam technology enables precise radiation delivery to individual cells or subcellular organelles.
Micro-irradiation techniques are crucial for exploring fundamental radiobiological response mechanisms.
Advancements in microbeam facilities worldwide allow for precisely defined beams of charged particles, X-rays, or electrons.

Purpose of the Study:

To review the developmental trajectory of microbeam technology.
To discuss various microbeam applications, emphasizing pre-clinical research.
To explore the translation of microbeam technology towards clinical applications.

Main Methods:

Review of literature on microbeam technology development and applications.
Analysis of microbeam capabilities for cellular and in vivo studies.
Examination of the transition towards therapeutic modalities like Microbeam Radiotherapy (MRT).

Main Results:

Microbeams serve as mechanistic probes for DNA damage response pathways.
Precise dose delivery facilitates the study of localized radiation effects.
Microbeam technology has paved the way for novel radiotherapy approaches.

Conclusions:

Microbeam technology has significantly advanced radiobiological research.
The precision of microbeams supports the development of targeted therapeutic strategies.
Microbeam Radiotherapy (MRT) represents a promising clinical translation of this technology.