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A Nonhuman Primate Model for Rectally Transmitted Syphilis

Cassandra Tansey1, Chunxia Zhao2, Andre Hopkins3

  • 1Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia.

The Journal of Infectious Diseases
|January 9, 2018
PubMed

Insights

Researchers created a new nonhuman primate model for rectal syphilis. This model helps study syphilis and HIV coinfection in men who have sex with men (MSM).

Area of Science:

  • Infectious Diseases
  • Primate Models
  • Virology

Background:

  • Syphilis and other rectal sexually transmitted infections (STIs) increase HIV risk in men who have sex with men (MSM).
  • Recent increases in US syphilis cases are concerning.
  • A nonhuman primate model for rectal syphilis is needed.

Purpose of the Study:

  • To develop the first nonhuman primate model for rectally transmitted syphilis.
  • To study Treponema pallidum infection with and without simian/human immunodeficiency virus (SHIV) coinfection.

Main Methods:

  • Rhesus macaques, both SHIV-infected and naive, were exposed to Treponema pallidum rectally.
  • The model mimics rectal transmission of syphilis.

Main Results:

  • All animals developed mucosal lesions.
  • Systemic dissemination of T. pallidum occurred in all animals.
  • All animals showed seroconversion, indicating treponemal antibody development.

Conclusions:

  • A novel nonhuman primate model for rectal syphilis has been established.
  • This model is valuable for studying syphilis manifestations and interventions.
  • The model is suitable for research on T. pallidum infection, with or without HIV coinfection.

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