Related Experiment Video
Updated: Feb 16, 2026
08:01
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
2.3K
Radical multimodality therapy for malignant pleural mesothelioma
Omar Abdel-Rahman1, Zeinab Elsayed, Hadeer Mohamed
1Clinical Oncology, Faculty of Medicine, Ain Shams University, Lofty Elsayed Street, Cairo, Egypt, 11335.
The Cochrane Database of Systematic Reviews
|January 9, 2018
Summary
Radical multimodal therapy for malignant pleural mesothelioma shows limited evidence of benefit and potential for increased harm. Current evidence suggests limiting these intensive treatments to clinical trials due to low quality data and lack of proven effectiveness.
Area of Science:
- Oncology
- Thoracic Surgery
- Radiation Oncology
- Clinical Trials
Background:
- Malignant pleural mesothelioma is a highly fatal cancer.
- Palliative platinum-based chemotherapy is the current standard treatment.
- The effectiveness of multimodal strategies remains uncertain.
Purpose of the Study:
- To evaluate the benefits and harms of radical multimodal treatment options for malignant pleural mesothelioma.
- To compare radical treatments against each other and against palliative approaches.
Main Methods:
- Systematic review of parallel-group randomized controlled trials (RCTs).
- Searched Cochrane Lung Cancer group's register, CENTRAL, MEDLINE, and Embase up to March 2017.
- Included RCTs measuring overall survival, quality of life, or adverse events.
Main Results:
- Two RCTs with 104 participants were included; both had a high risk of bias.
- Evidence quality for overall survival was moderate, and low for other outcomes.
- No significant difference in overall survival or quality of life was found; one trial reported more serious adverse events with radical treatment.
Conclusions:
- Low overall strength of evidence and lack of support for routine use of radical multimodal therapy.
- Potential for increased harm and cost without proven benefit.
- Radical multimodal interventions should be confined to clinical trials.
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