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Biochemical basis for pharmacological intervention as a reprogramming strategy against hypertension and kidney

You-Lin Tain1, Samuel H H Chan2, Julie Y H Chan2

  • 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

Biochemical Pharmacology
|January 9, 2018
PubMed

Insights

Early life insults can program hypertension and kidney disease. This review explores reprogramming strategies, like early pharmacological interventions, to prevent these conditions, pending clinical validation.

Area of Science:

  • Developmental biology
  • Nephrology
  • Cardiovascular medicine
  • Pharmacology

Background:

  • The developmental origins of health and disease (DOHaD) concept links early-life insults to adult-onset hypertension and kidney disease.
  • Current therapeutic strategies primarily focus on adult interventions, often after disease manifestation.

Purpose of the Study:

  • To review the evidence for kidney developmental programming leading to hypertension and kidney disease.
  • To explore pharmacological interventions as reprogramming strategies for early-life protection against these conditions.

Main Methods:

  • Literature review of studies investigating DOHaD principles in kidney development.
  • Analysis of animal studies on pharmacological interventions for developmental programming.

Main Results:

  • Evidence supports early-life insults programming mechanisms that predispose to hypertension and kidney disease.
  • Animal studies indicate potential efficacy of pharmacological interventions in long-term protection.

Conclusions:

  • Shifting therapeutic focus to early life, guided by DOHaD, offers a promising strategy.
  • Clinical validation of pharmacological reprogramming strategies is crucial, requiring identification of optimal timing, dosage, and duration.

Keywords:
Chronic kidney diseaseDevelopmental origins of health and disease (DOHaD)HypertensionNephron endowmentOxidative stressRenin-angiotensin systemReprogramming

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