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Flow analysis with chemiluminescence detection: Recent advances and applications
Irina I Timofeeva1, Christina S Vakh1, Andrey V Bulatov1
1Department of Analytical Chemistry, Institute of Chemistry, Saint-Petersburg University, St.Petersburg State University, SPbSU, SPbU, 7/9 Universitetskayanab., St. Petersburg 199034, Russia.
Talanta
|January 10, 2018
Summary
This review covers key advancements in flow analysis using chemiluminescence (CL) detection. It details compatible systems, detectors, reactions, sample prep, and recent applications across various matrices.
Area of Science:
- Analytical Chemistry
- Spectroscopy
Background:
- Flow analysis offers advantages for high-throughput and automated chemical measurements.
- Chemiluminescence (CL) detection provides high sensitivity and selectivity for various analytes.
Purpose of the Study:
- To review significant developments in flow analysis coupled with chemiluminescence detection.
- To summarize recent applications (post-2010) across diverse sample matrices.
- To discuss emerging trends in this analytical field.
Main Methods:
- Literature review focusing on developments in flow systems, detector designs, and sample treatment for CL detection.
- Classification and tabulation of recent applications based on sample matrix (food, environmental, pharmaceutical, biological).
- Analysis of commonly applied CL reactions and their performance metrics (linear range, LOD).
Main Results:
- Identification of various flow systems and detector designs compatible with CL detection.
- Detailed presentation of applications in food/beverages, environmental samples, pharmaceuticals, and biological fluids.
- Compilation of performance data, including linear ranges and limits of detection for numerous analytes.
Conclusions:
- Flow analysis with CL detection is a versatile and sensitive technique for diverse applications.
- Recent advancements have expanded its utility in complex matrices.
- Future trends point towards further integration and miniaturization.
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