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The association between methionine synthase A2756G polymorphism and hematological cancer: A meta-analysis

Bing Wu1, Kang Liu, Jun-Ping Yang

  • 1Tumor Treatment Center, Renmin Hospital of Wuhan University, Hubei Department of Radiotherapy, The First Affiliated Hospital of Guangxi Medical University, Guangxi State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.

Medicine
|January 10, 2018
PubMed
Abstract

Insights

The methionine synthase (MS) A2756G polymorphism is not associated with an increased risk of hematological cancer. This meta-analysis of over 24,000 individuals found no significant link between the MS A2756G variant and cancer development.

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • The association between methionine synthase (MS) A2756G polymorphism and hematological cancer risk has been investigated in numerous studies.
  • Existing research presents inconsistent findings, necessitating a comprehensive meta-analysis to clarify this relationship.

Purpose of the Study:

  • To conduct a meta-analysis to precisely estimate the association between the MS A2756G polymorphism and the risk of developing hematological cancer.
  • To synthesize evidence from multiple studies to provide a more robust conclusion on the genetic risk factor.

Main Methods:

  • A meta-analysis was performed, pooling data from 25 articles comprising 26 distinct studies.
  • The analysis included a total of 8,641 hematological cancer patients and 15,498 healthy controls.
  • Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for various genetic models to assess the association.

Main Results:

  • No statistically significant increased risks were observed for the MS A2756G polymorphism in relation to hematological cancer across all evaluated genetic models (allelic homozygote, heterozygote, dominant, and recessive).
  • Stratified analyses based on ethnicity and the source of control groups also revealed no significant associations.
  • Specific ORs and P-values indicated no deviation from the null hypothesis for all comparisons.

Conclusions:

  • The findings suggest that the MS A2756G polymorphism is unlikely to be a significant risk factor for hematological cancer.
  • Further research may be warranted, but current evidence does not support a causal link between this specific genetic variant and cancer susceptibility.

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