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Association of rs662799 in APOA5 with CAD in Chinese Han population

Hua Chen1,2, Shifang Ding3,4, Mi Zhou1

  • 1Department of Cardiology, Southern Medical University, Guangzhou, Guangdong, China.

BMC Cardiovascular Disorders
|January 10, 2018
PubMed

Insights

Genetic factors influence coronary artery disease (CAD). A study in the Chinese Han population found the rs662799 variant in APOA5 is a risk factor for CAD.

Area of Science:

  • Genetics
  • Cardiovascular Disease Research
  • Population Genetics

Background:

  • Coronary Artery Disease (CAD) is a complex condition influenced by genetic and environmental factors.
  • Previous studies on single nucleotide polymorphisms (SNPs) and CAD risk have yielded inconsistent results.
  • Investigating genetic associations within specific populations, like the Chinese Han population, is crucial for understanding CAD etiology.

Purpose of the Study:

  • To investigate the genetic basis of CAD in the Chinese Han population.
  • To analyze the association of 7 SNPs within the lipid metabolism pathway with CAD risk.
  • To identify specific genetic variants contributing to CAD susceptibility in this demographic.

Main Methods:

  • Utilized a cohort of 631 individuals, comprising 435 CAD cases and 196 healthy controls.
  • Employed multiplex PCR amplification followed by next-generation sequencing (NGS) for SNP genotyping.
  • Conducted association analyses to evaluate the relationship between selected SNPs and CAD.

Main Results:

  • The rs662799 SNP in the Apolipoprotein A5 (APOA5) gene was significantly associated with increased CAD risk (OR=1.374, P=0.03).
  • No significant association was found for the other tested SNPs in the overall cohort.
  • Stratified analyses indicated associations for rs5882 in non-hypertensive individuals (OR=1.593, P=0.023) and rs1800588 in smokers (OR=1.603, P=0.035).

Conclusions:

  • The minor allele of rs662799 is identified as a risk factor for coronary artery disease in the Chinese Han population.
  • Specific SNPs may confer CAD risk in a population-dependent manner or within subgroups.
  • Further research is warranted to elucidate the role of these genetic variants in CAD pathogenesis.
Abstract

Keywords:
Case-control studyChinese Han populationCoronary artery diseaseSingle nucleotide polymorphisms

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