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Biomarkers of inflammation in infants with cystic fibrosis

Theresa A Laguna1, Cynthia B Williams2, Myra G Nunez2

  • 1Minnesota CF Center, Department of Pediatrics, University of Minnesota Masonic Children's Hospital, 420 Delaware St. SE; MMC-742, Minneapolis, MN, 55455, USA. lagun005@umn.edu.

Respiratory Research
|January 10, 2018
PubMed

Insights

Cathepsin B and club cell secretory protein (CCSP) show potential as biomarkers for inflammation in infants with cystic fibrosis (CF). These markers may help identify children at risk for progressive lung disease.

Area of Science:

  • Biomarkers and diagnostics
  • Pediatric respiratory medicine
  • Inflammation research

Background:

  • Urgent need for biomarkers in cystic fibrosis (CF) to predict disease progression and serve as clinical trial endpoints.
  • Focus on identifying early indicators in asymptomatic CF infants.

Purpose of the Study:

  • Investigate targeted biomarkers (desmosine, CCSP, cathepsin B) in asymptomatic CF infants.
  • Assess biomarker potential for identifying risk and monitoring disease.

Main Methods:

  • Collected urine, blood, and lung function data from CF infants and healthy controls over 2 years.
  • Performed bronchoscopy with lavage in a subset of CF infants.
  • Measured biomarker concentrations and analyzed associations with clinical factors using mixed-effects models and ROC curves.

Main Results:

  • Urinary cathepsin B was significantly higher in CF infants versus healthy infants.
  • Cathepsin B and CCSP levels in CF infants were lower than in adult CF patients.
  • CF infant airway CCSP was significantly higher than in adult CF patients and negatively associated with IL-8.

Conclusions:

  • Cathepsin B and CCSP show promise as biomarkers of inflammation in CF infants.
  • Further research is warranted to validate these findings and their clinical utility.
Abstract

Keywords:
Bronchoalveolar lavage fluidInfectionInflammationLung functionPediatrics

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