Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A patient-specific treatment model for Graves' hyperthyroidism.

Balamurugan Pandiyan1, Stephen J Merrill2, Flavia Di Bari3

  • 1Department of Mathematics, University of Wisconsin - Whitewater, 800 W. Main Street, Whitewater, 53190, WI, USA. balamurugan.pandiyan@gmail.com.

Theoretical Biology & Medical Modelling
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis.

Frontiers in oncology·2021
Same author

The microbiological profile of patients with Fournier's gangrene: A retrospective multi-institutional cohort study.

Urologia·2021
Same author

Rotterdam mobile phone app including MRI data for the prediction of prostate cancer: A multicenter external validation.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2021
Same author

The Influence of Endogenous Testosterone on Incidental Prostate Cancer after Transurethral Prostate Resection.

Urologia internationalis·2021
Same author

Corrigendum to 'Development of a Novel Risk Score to Select the Optimal Candidate for Cytoreductive Nephrectomy Among Patients with Metastatic Renal Cell Carcinoma. Results from a Multi-institutional Registry (REMARCC)' [European Urology Oncology 3 (2021) 256-263].

European urology oncology·2021
Same author

Cytokines as Targets of Novel Therapies for Graves' Ophthalmopathy.

Frontiers in endocrinology·2021
Same journal

The impact of natural disasters on the spread of COVID-19: a geospatial, agent-based epidemiology model.

Theoretical biology & medical modelling·2024
Same journal

Assessing countermeasures during a hepatitis A virus outbreak among men who have sex with men.

Theoretical biology & medical modelling·2021
Same journal

The effect of men who have sex with men (MSM) on the spread of sexually transmitted infections.

Theoretical biology & medical modelling·2021
Same journal

Analysis of international traveler mobility patterns in Tokyo to identify geographic foci of dengue fever risk.

Theoretical biology & medical modelling·2021
Same journal

Markov modelling of viral load adjusting for CD4 orthogonal variable and multivariate conditional autoregressive mapping of the HIV immunological outcomes among ART patients in Zimbabwe.

Theoretical biology & medical modelling·2021
Same journal

On the relationship between inhibition and receptor occupancy by nondepolarizing neuromuscular blocking drugs.

Theoretical biology & medical modelling·2021
See all related articles

This study models Graves' disease treatment using Methimazole (MMI). The model simulates patient progression from hyperthyroidism to euthyroidism, aiding in personalized MMI dosing and treatment duration decisions for better outcomes.

Area of Science:

  • Endocrinology
  • Computational Biology
  • Pharmacology

Background:

  • Graves' disease is an autoimmune disorder causing hyperthyroidism via thyroid receptor antibodies (TRAb).
  • Thyroid stimulating hormone (TSH) mimics TRAb action, stimulating the thyroid hormone receptor (TSHR).
  • Methimazole (MMI) is a standard treatment for hyperthyroidism in Graves' disease patients.

Purpose of the Study:

  • To develop a mathematical model simulating hyperthyroidism treatment with MMI.
  • To predict patient response to MMI therapy and optimize treatment schedules.
  • To guide clinical decisions regarding MMI dosage and discontinuation based on physiological parameters.

Main Methods:

  • Developed an ordinary differential equation model with four state variables: MMI concentration, free thyroxine (FT4), TRAb concentration, and thyroid gland size.
Keywords:
Graves’ diseaseHyperthyroidismMethimazoleThyroid receptor antibodies

Related Experiment Videos

  • Incorporated thirteen parameters to simulate disease progression.
  • Validated model predictions against clinical data from four patients.

    • Main Results:

    • Without MMI, a stable hyperthyroid state exists.
    • MMI treatment shifts the state from hyperthyroidism towards subclinical hyperthyroidism and then euthyroidism.
    • Model simulations accurately reflect patient data progression.

    Conclusions:

    • The model can describe, test, and predict patient treatment schedules for Graves' disease.
    • It facilitates personalized MMI dosing, including loading and maintenance doses.
    • The model aids in determining optimal MMI discontinuation timing based on FT4 levels to maintain euthyroidism and prevent relapse.