SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation

Area of Science:

• Dermatology
• Immunology
• Pharmacology
• Genetics

Background:

• Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening drug-induced hypersensitivity reaction.
• High morbidity and mortality associated with SJS/TEN necessitate improved clinical care and research.
• Multidisciplinary collaboration is crucial for advancing SJS/TEN management and prevention.

Purpose of the Study:

• To convene experts from diverse disciplines to consolidate current knowledge on SJS/TEN.
• To identify key areas for future research and clinical practice improvement.
• To foster a sustainable network for SJS/TEN research and patient care.

Main Methods:

• An investigator-driven meeting was held prior to the American Academy of Dermatology Annual meeting.
• Clinicians and scientists from multiple disciplines involved in SJS/TEN care and research were assembled.
• Expert opinions and current knowledge were summarized across various SJS/TEN-related topics.

Main Results:

• The article provides a comprehensive overview of SJS/TEN, encompassing epidemiology, pharmacogenomics, clinical management, and special populations.
• It addresses regulatory aspects, electronic health records, novel causative agents, and immunopathogenesis.
• The patient perspective on SJS/TEN was also included.

Conclusions:

• A durable, multidisciplinary network is essential for advancing SJS/TEN scientific progress.
• This network aims to translate research findings into improved prevention, early diagnosis, and management of SJS/TEN.
• Enhanced collaboration will reduce the burden of SJS/TEN on patients and society.