Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.7K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.7K
Types of Functions I01:26

Types of Functions I

319
Functions are fundamental mathematical tools that capture relationships between variables and describe how one quantity changes in relation to another. Their diverse forms allow them to model various real-world phenomena with precision and flexibility. Among the various categories, algebraic functions are prominent due to their formulation through basic arithmetic operations: addition, subtraction, multiplication, division, and root extraction.Algebraic functions include polynomial, rational,...
319
Types of Functions II01:19

Types of Functions II

208
Trigonometric and exponential functions are essential mathematical tools used to model distinct types of real-world behavior, particularly in periodic and growth-related phenomena. These functions extend the capabilities of basic algebraic models by capturing recurring cycles and rapid changes across various scientific and engineering contexts.Trigonometric functions, such as sine and cosine, are particularly effective for representing periodic phenomena. Their cyclic behavior makes them...
208
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

9.9K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
9.9K
Types of Functions III01:28

Types of Functions III

273
Logarithmic and piecewise functions play central roles in mathematical modeling, particularly when capturing nonlinear or segmented behaviors in real-world phenomena. Although these functions differ fundamentally in structure and application, both serve to represent complex relationships in simplified mathematical terms.A logarithmic function is defined as the inverse of an exponential function, expressed as These functions grow quickly for small values of x but slow down as x increases,...
273
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tenascin-C orchestrates radiotherapy-induced head and neck tumor regression.

EMBO molecular medicine·2026
Same author

Therapeutic Potential of Fingolimod and Dimethyl Fumarate in Preclinical Pancreatic Cancer Models.

Oncology research·2026
Same author

Hybrid Extracellular Vesicles for Efficient Loading and Functional Delivery of mRNA.

Journal of extracellular vesicles·2025
Same author

Targeting the extracellular matrix with Tenascin-C-specific CAR T cells extends survival in preclinical models of glioblastoma.

Journal for immunotherapy of cancer·2025
Same author

Synovial matrix turnover controls immune cell spatial patterning in inflammation resolution.

Molecular systems biology·2025
Same author

"I was largely unguided trying to figure it out on my own": Experiences of genital tucking among transfeminine and gender diverse individuals.

International journal of transgender health·2025

Related Experiment Video

Updated: Feb 16, 2026

Translating Ribosome Affinity Purification TRAP to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
09:41

Translating Ribosome Affinity Purification TRAP to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale

Published on: May 14, 2020

13.0K

Investigating cell-type specific functions of tenascin-C.

Devadarssen Murdamoothoo1, Anja Schwenzer2, Jessica Kant1

  • 1Inserm U1109, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy (MNT3) Team, Strasbourg, France; Université de Strasbourg, LabEx Medalis, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France.

Methods in Cell Biology
|January 10, 2018
PubMed
Summary

Tenascin-C (TNC) is crucial in tissue repair, immunity, and angiogenesis. Assays detailed here explore TNC's effects on cell behavior and its role in various diseases, aiding further research.

Keywords:
Actin cytoskeletonCell adhesionChicken chorioallantoic membrane assayEndothelial cellImmune cell activationImmunofluorescenceMatrigel tubulogenesis assayProliferation assaySurvival assaySynovial fibroblastTenascin-CWound healing assayextracellular matrix

More Related Videos

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana
10:10

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Published on: May 29, 2010

16.3K
Heterokaryon Technique for Analysis of Cell Type-specific Localization
09:31

Heterokaryon Technique for Analysis of Cell Type-specific Localization

Published on: March 11, 2011

17.0K

Related Experiment Videos

Last Updated: Feb 16, 2026

Translating Ribosome Affinity Purification TRAP to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
09:41

Translating Ribosome Affinity Purification TRAP to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale

Published on: May 14, 2020

13.0K
Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana
10:10

Investigating Tissue- and Organ-specific Phytochrome Responses using FACS-assisted Cell-type Specific Expression Profiling in Arabidopsis thaliana

Published on: May 29, 2010

16.3K
Heterokaryon Technique for Analysis of Cell Type-specific Localization
09:31

Heterokaryon Technique for Analysis of Cell Type-specific Localization

Published on: March 11, 2011

17.0K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Tenascin-C (TNC) is an extracellular matrix protein with significant roles in tissue repair, inflammation, fibrosis, and cancer.
  • Mouse models have confirmed TNC's importance in immunity and angiogenesis.
  • Existing research utilizes cell and organ cultures to understand TNC's in vivo mechanisms.

Purpose of the Study:

  • To describe assays investigating tenascin-C's (TNC) antiadhesive properties.
  • To measure TNC's effects on cell cytoskeleton, survival, proliferation, and migration.
  • To assess TNC's impact on endothelial and immune cells and compare fibroblast responses.

Main Methods:

  • Investigating TNC's antiadhesive properties through specific assays.
  • Measuring TNC's influence on cellular processes like actin cytoskeleton dynamics, survival, proliferation, and migration.
  • Utilizing cell and organ cultures to study TNC's effects on endothelial and immune cells.
  • Comparing responses of fibroblasts from normal and diseased tissues to TNC.

Main Results:

  • Assays were developed to quantify TNC's impact on cell behavior.
  • TNC's role in modulating endothelial and immune cell function was investigated.
  • Differential responses of fibroblasts from healthy versus diseased tissues were observed.

Conclusions:

  • The described assays provide valuable tools for studying tenascin-C's functions.
  • Understanding TNC's cellular mechanisms is critical for its role in disease.
  • Further research can leverage these methods to explore TNC in various pathological contexts.