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Integrins

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Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Related Experiment Video

Updated: Feb 16, 2026

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling

Published on: November 3, 2015

Integrins in Vascular Development and Pathology.

Paola A Guerrero¹, Joseph H McCarty¹

¹University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Advances in Pharmacology (San Diego, Calif.)

|January 10, 2018

Summary

This summary is machine-generated.

Integrins are key cell receptors in blood vessel development, mediating communication between endothelial cells and stromal cells. Their dysfunction is linked to vascular diseases, highlighting their therapeutic potential.

Keywords:

Angiogenesis Cell adhesion Extracellular matrix Neurovascular Signal transduction

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Last Updated: Feb 16, 2026

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Published on: April 25, 2019

Area of Science:

Cell Biology
Vascular Biology
Biochemistry

Background:

Endothelial cells (ECs) and stromal cells interact via extracellular matrix (ECM) proteins and integrin receptors.
Integrin-mediated adhesion and signaling are vital for vascular development and physiology.
Altered integrin function contributes to vascular pathologies like thrombosis, autoimmune disorders, and cancer.

Purpose of the Study:

To discuss integrin adhesion and signaling pathways critical for EC growth, survival, and migration.
To explore integrin-mediated paracrine signaling between ECs and stromal cells in the microenvironment.
To review the role of integrins in vascular diseases and potential therapeutic targets.

Main Methods:

Literature review and synthesis of existing research on integrin signaling in vascular biology.
Analysis of autocrine and paracrine signaling mechanisms involving ECM proteins and integrins.
Examination of the pathological roles of integrins in vascular diseases.

Main Results:

Integrin pathways are essential for regulating endothelial cell behavior during vascular development.
Paracrine signaling mediated by integrins establishes crucial links between endothelial and stromal cells.
Dysregulation of integrin function is a significant factor in the pathogenesis of various vascular disorders.

Conclusions:

Integrin adhesion and signaling pathways are fundamental to vascular homeostasis and development.
Targeting integrin pathways offers promising therapeutic strategies for vascular pathologies.
Understanding EC-stromal cell interactions via integrins is key to advancing vascular medicine.