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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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Related Experiment Video

Updated: Feb 16, 2026

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
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Microarray expression profile analysis of long non-coding RNAs in thoracic aortic aneurysm.

Yang Li1, Nan Yang2

  • 1Department of General Surgery, Beijing Yuho Rehabilitation Hospital of Integrated Chinese and Western Medicine, Beijing, China.

The Kaohsiung Journal of Medical Sciences
|January 10, 2018
PubMed
Summary

This study identified numerous long non-coding RNAs (lncRNAs) differentially expressed in thoracic aortic aneurysm (TAA). Specific lncRNAs, like RP11-465L10.10, show potential as biomarkers and therapeutic targets for TAA.

Keywords:
Long non-coding RNAMicroarrayThoracic aortic aneurysm

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Area of Science:

  • Cardiovascular Biology
  • Molecular Genetics
  • RNA Biology

Background:

  • Thoracic aortic aneurysm (TAA) is a life-threatening vascular condition.
  • Long non-coding RNAs (lncRNAs) are emerging regulators in cardiovascular physiology and pathology.
  • Limited research exists on the role of lncRNAs in TAA development.

Purpose of the Study:

  • To profile differential lncRNA expression in TAA.
  • To identify candidate lncRNAs associated with TAA pathogenesis.
  • To explore potential RNA-protein interactions for TAA biomarkers and therapeutics.

Main Methods:

  • Third-generation lncRNA microarray analysis of human TAA and control aortic tissues.
  • Bioinformatic analysis including differential expression, conservation scoring, and tissue specificity.
  • RNA-protein interaction prediction using catRAPID.

Main Results:

  • Identified 1352 up-regulated and 1624 down-regulated lncRNAs in TAA.
  • Selected 5 highly aorta-expressed lncRNAs, including HIF1A-AS1, RP11-465L10.10, LOC100506472, CTD-2184D3.5, and RP-399O19.5.
  • RP11-465L10.10 demonstrated a strong interaction with MZF1, a transcription factor for MMP9.

Conclusions:

  • This study presents comprehensive lncRNA expression profiles in TAA.
  • Identified specific lncRNAs, particularly RP11-465L10.10, as potential biomarkers and therapeutic targets for TAA.
  • The findings provide novel insights into the molecular mechanisms underlying TAA.