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[Stem cells: searching predisposition to cardiac commitment by surface markers expression]

Luis A Lara-Martínez1, Ingrid Gutiérrez-Villegas1, Victor M Arenas-Luna1

  • 1Laboratorio de Biología Molecular, Escuela de Medicina, Universidad Panamericana, Ciudad de México, México.

Archivos De Cardiologia De Mexico
|January 10, 2018
PubMed

Insights

Stem cell therapy shows promise for cardiovascular diseases. Adult stem cells, particularly mesenchymal stem cells (MSCs), may offer a viable alternative to cardiac stem cells (CSCs) due to accessibility and potential cardiac differentiation.

Area of Science:

  • Regenerative Medicine
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Cardiovascular diseases are a leading global cause of mortality and a significant economic burden.
  • Stem cell therapy is a promising therapeutic strategy for treating heart conditions.
  • Current limitations exist with cardiac stem cells (CSCs), including inaccessibility and procurement risks.

Purpose of the Study:

  • To compare surface markers of cardiac stem cells (CSCs) with other adult stem cells.
  • To identify potential cardiac progenitor cells within adult stem cell populations.
  • To explore alternative stem cell sources for cardiovascular regenerative therapy.

Main Methods:

  • Review and analysis of existing literature on stem cell surface markers.
  • Comparative immunophenotypic analysis of CSCs and other adult stem cells (e.g., bone marrow, adipose-derived).
  • Evaluation of the potential for cardiac differentiation in identified adult stem cell subpopulations.

Main Results:

  • Certain adult stem cells share specific surface markers with CSCs, suggesting potential cardiac progenitor populations.
  • These identified subpopulations, though present in low proportions, exhibit a predictable immunophenotype.
  • The potential for cardiac differentiation in these adult stem cells may be comparable to CSCs.

Conclusions:

  • Adult stem cells, particularly mesenchymal stem cells (MSCs), represent a promising and accessible source for cardiovascular therapy.
  • Identification of CSC-like surface markers in adult stem cells supports their potential for cardiac differentiation.
  • Further research into these specific adult stem cell subpopulations could enhance their therapeutic value in treating myocardial infarction and other cardiovascular diseases.

Keywords:
Cardiac stem cellCell regenerationCélula madre cardiacaCélula mesenquimalDiferenciaciónDifferentiationMarcador de superficieMesenchymal cellMéxicoRegeneración celularSurface marker

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