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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Enhanced Efflux Pump Activity in Old Candida glabrata Cells

Somanon Bhattacharya1, Bettina C Fries2,3

  • 1Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

Antimicrobial Agents and Chemotherapy
|January 10, 2018
PubMed
Summary

Replicative aging in Candida glabrata increases antifungal resistance. Older cells show higher ABC transporter and efflux pump activity, enhancing tolerance to fluconazole, micafungin, and amphotericin B.

Keywords:
Candida glabrataagingantifungal resistancedrug resistance mechanismsefflux pumps

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