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Updated: Feb 16, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch
Janetta Top1, Jan C Sinnige2, Ellen C Brouwer2
1Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands j.top@umcutrecht.nl.
Abstract:
Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.
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