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mTOR signaling in stem and progenitor cells

Delong Meng1,2,3, Anderson R Frank1,2,3, Jenna L Jewell4,2,3

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Development (Cambridge, England)
|January 10, 2018
PubMed

Insights

The mammalian target of rapamycin (mTOR) pathway is crucial for cell growth and metabolism. New research highlights mTOR

Area of Science:

  • Cellular Biology
  • Biochemistry
  • Developmental Biology

Background:

  • The mammalian target of rapamycin (mTOR) pathway regulates fundamental cellular processes like growth, metabolism, and autophagy.
  • mTOR signaling is implicated in various human diseases, including cancer, diabetes, and aging.
  • Recent discoveries reveal novel functions of mTOR in stem cell biology.

Purpose of the Study:

  • To review the recent advances in understanding mTOR signaling in stem and progenitor cells.
  • To provide an overview of mTOR's role in adult stem cell differentiation and proliferation.
  • To discuss the implications of mTOR in multipotent stem cell differentiation programs.

Main Methods:

  • Literature review of recent studies on mTOR signaling.
  • Analysis of research on mTOR's function in murine and human stem cells.
  • Synthesis of findings on mTOR's role in cell growth, metabolism, and differentiation.

Main Results:

  • mTOR signaling is essential for promoting adult stem cell differentiation.
  • mTOR drives the growth and proliferation of stem and progenitor cells.
  • mTOR dictates the differentiation pathways of multipotent stem cell populations.

Conclusions:

  • mTOR plays a critical role in regulating the behavior of stem and progenitor cells.
  • Understanding mTOR signaling in stem cells opens new avenues for regenerative medicine and disease treatment.
  • Further research into mTOR's precise mechanisms in stem cells is warranted.
Keywords:
Amino acidsMetabolismSignalingStem cellmTOR

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