Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Anchoring-and-Adjustment Heuristic01:25

The Anchoring-and-Adjustment Heuristic

7.8K
In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.8K
The Representativeness Heuristic02:13

The Representativeness Heuristic

16.8K
The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
16.8K
Anchoring Junctions01:03

Anchoring Junctions

5.1K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
5.1K
Lipids as Anchors01:32

Lipids as Anchors

7.5K
In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
7.5K
Areas Within Irregular Boundaries01:26

Areas Within Irregular Boundaries

388
Calculating areas within irregular boundaries, such as along rivers or curved roads, is crucial in various fields, including surveying, engineering, and environmental management. Surveyors often begin by creating a traverse, a connected series of straight lines approximating the area's boundary. The coordinates of each traverse point are essential for calculating the enclosed area. The double meridian distance formula is a widely used technique for this purpose. This method utilizes the...
388
GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

5.6K
GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Focused ultrasound for blood-brain barrier opening in brain tumor patients: Technical nuances.

Neuro-oncology advances·2026
Same author

Environmental representations in mouse hippocampal CA1 reflect the predictive structure of navigation.

Current biology : CB·2025
Same author

Rotating visual spaces induce behavioral biases consistent with recalibrated heading integration in humans.

iScience·2025
Same author

Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms.

eLife·2025
Same author

Identifying representational structure in CA1 to benchmark theoretical models of cognitive mapping.

Neuron·2024
Same author

Binge ethanol consumption can be attenuated by systemic administration of minocycline and is associated with enhanced neuroinflammation in the central amygdala.

Neuropharmacology·2024
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
Same journal

Noninvasive decoding of typed sentences from human brain activity.

Nature neuroscience·2026
Same journal

Striatal control of amygdalar acetylcholine release during salience-associated processing.

Nature neuroscience·2026
Same journal

Mitochondrial stress response drives microglial senescence.

Nature neuroscience·2026
Same journal

Conditioned accumbal dopamine transients forecast individual preference for drug versus natural rewards and compulsive behavior.

Nature neuroscience·2026
Same journal

The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.

Nature neuroscience·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.6K

Human entorhinal cortex represents visual space using a boundary-anchored grid.

Joshua B Julian1, Alexandra T Keinath2, Giulia Frazzetta2

  • 1Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA. joshua.b.julian@gmail.com.

Nature Neuroscience
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Human brain's entorhinal cortex uses a grid system to represent visual space, influenced by environmental boundaries. This finding, observed during a visual search task, suggests a shared spatial representation mechanism with rodents.

More Related Videos

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
09:45

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

16.1K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.9K

Related Experiment Videos

Last Updated: Feb 15, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

10.6K
Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
09:45

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

16.1K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.9K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Spatial Navigation

Background:

  • The entorhinal cortex is crucial for spatial memory and navigation.
  • Rodents utilize grid cells in their entorhinal cortex for representing navigable space.

Purpose of the Study:

  • To investigate how the human entorhinal cortex represents visual space.
  • To determine if human entorhinal cortex employs a grid-like spatial representation.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure brain activity.
  • Participants performed a visual search task within a bounded environment.

Main Results:

  • Entorhinal cortex activity showed a periodic modulation related to gaze-movement direction.
  • The orientation of this modulation was dependent on the boundaries of the visual search space.

Conclusions:

  • The human entorhinal cortex represents visual space using a boundary-anchored grid system.
  • This suggests a conserved mechanism for spatial representation across species.