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Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

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Published on: May 24, 2011

Cholinergic Modulation of Type 2 Immune Responses.

Goele Bosmans¹, Gabriel Shimizu Bassi¹, Morgane Florens¹

¹Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Frontiers in Immunology

|January 10, 2018

Summary

The nervous and immune systems interact, influencing health and disease. This review explores how the parasympathetic nervous system, via cholinergic pathways, impacts allergic inflammation and may offer new therapeutic targets.

Keywords:

allergic inflammation cholinergic anti-inflammatory pathway neuroimmune interactions parasympathetic nervous system type 2 immunity vagus nerve

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Area of Science:

Neuroimmunology
Allergic Inflammation Research

Background:

The bidirectional communication between the nervous and immune systems is crucial for homeostasis and inflammation.
The cholinergic anti-inflammatory pathway highlights the parasympathetic nervous system's role in regulating immune responses.

Purpose of the Study:

To review the role of the parasympathetic nervous system in allergic diseases.
To highlight cholinergic modulation of allergic inflammatory responses.

Main Methods:

Literature review focusing on neuroimmunology and allergic diseases.
Analysis of studies on nicotinic and muscarinic receptor roles in inflammation.

Main Results:

The parasympathetic nervous system influences allergic diseases like rhinitis, asthma, and atopic dermatitis.
Cholinergic receptors (nicotinic and muscarinic) modulate barrier function, immune cell responses, and allergic inflammation.

Conclusions:

Cholinergic pathways are integral to type 2 immune responses in allergic conditions.
Understanding these pathways may lead to novel therapeutic strategies for allergic diseases.