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Related Concept Videos

Self-Presentation01:25

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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Strategies of Self-Presentation I: Strategic Self-Presentation01:12

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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
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Processes of Self-Presentation01:29

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Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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Antigen Presenting Cells01:22

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
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Strategies of Self-Presentation II: Self-Verification01:17

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Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
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Related Experiment Video

Updated: Feb 15, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
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Antigen Presentation by Vascular Cells.

Jordan S Pober1, Jonathan Merola2, Rebecca Liu1

  • 1Department of Immunobiology, Yale School of Medicine, New Haven, CT, United States.

Frontiers in Immunology
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Vessel wall cells, like endothelial cells, present antigens to T cells, initiating immune responses. Targeting these vascular cells offers new strategies for modulating immune responses in transplantation and disease.

Keywords:
effector memory T cellsendothelial cellspericytesregulatory T cellssmooth muscle cellstransendothelial migration

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Area of Science:

  • Immunology
  • Vascular Biology
  • Transplantation Science

Background:

  • Cells within blood vessel walls, including endothelial cells (ECs), can present peptide antigens via major histocompatibility complex (MHC) molecules.
  • This presentation can be recognized by circulating effector memory T cells (TEM), initiating immune responses without professional antigen-presenting cells.
  • Vascular cells express co-stimulatory molecules and cytokines that modulate T cell activation and migration.

Purpose of the Study:

  • To explore the role of vascular cells in initiating and regulating immune responses.
  • To investigate the potential of targeting vascular cells for therapeutic interventions in transplantation and autoimmune diseases.
  • To understand how endothelial cells and mural cells contribute to T cell activation and extravasation.

Main Methods:

  • Review of existing literature on antigen presentation by vascular cells.
  • Analysis of molecular interactions between endothelial cells, mural cells, and T cells.
  • Discussion of potential therapeutic strategies involving genetic manipulation or siRNA targeting of vascular cells.

Main Results:

  • Vascular cells can initiate localized memory immune responses in peripheral tissues.
  • Antigen presentation by ECs can trigger TEM transendothelial migration and activation, contributing to allograft rejection, infection defense, and autoimmunity.
  • Mural cells like pericytes and smooth muscle cells can further regulate T cell responses after extravasation.

Conclusions:

  • Targeting vascular cells presents a novel strategy for modulating immune responses.
  • Reducing MHC expression on ECs via siRNA may mitigate rejection in organ transplantation.
  • Genetic modification of vascular cells can enhance the perfusion of tissue-engineered organs and prevent rejection.