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Aging increases the expression of lung CINCs and MCP-1 in senile patients with pneumonia

Wei Li1, Cheng Ding2, Shaojun Yin3

  • 1Department of Geriatrics, Shanghai Tenth People's Hospital Affiliated to Tongji University, Tongji University School of Medicine, Shanghai, 200072, China.

Oncotarget
|January 10, 2018
PubMed
Abstract

Insights

Aging increases monocyte chemoattractant protein-1 (MCP-1) and cytokine-induced neutrophil chemoattractant (CINC) expression in pneumonia patients. This may elevate pneumonia risk in the elderly.

Area of Science:

  • Immunology
  • Gerontology
  • Infectious Diseases

Background:

  • Pneumonia presents a significant health concern, particularly in elderly populations.
  • The role of specific inflammatory mediators in age-related pneumonia outcomes requires further elucidation.

Purpose of the Study:

  • To investigate the association between aging and the expression of key chemoattractant proteins in pneumonia patients.
  • To compare the levels of monocyte chemoattractant protein-1 (MCP-1) and cytokine-induced neutrophil chemoattractants (CINCs) between senile and non-senile pneumonia patient groups.

Main Methods:

  • A cohort of 800 hospitalized pneumonia patients was divided into senile and non-senile groups.
  • Automated blood cell analysis was used for bacterial, white blood cell, and neutrophil counts.
  • Enzyme-linked immunosorbent assay (ELISA) determined the expression levels of MCP-1, CINC-1, CINC-2α, CINC-2β, and CINC-3.

Main Results:

  • Senile pneumonia patients exhibited higher bacterial counts and lower white blood cell and neutrophil counts compared to non-senile patients.
  • Significantly elevated concentrations of MCP-1, CINC-1, and CINC-2α were observed in the senile group across all pathogen types.
  • Expression differences for MCP-1, CINC-1, and CINC-2α were noted in patients with specific pathogens, while CINC-2β and CINC-3 were undetectable.

Conclusions:

  • Aging is associated with increased expression of MCP-1, CINC-1, and CINC-2α in pneumonia patients.
  • These elevated inflammatory mediator levels in the elderly may contribute to an increased susceptibility and risk of developing pneumonia.
Keywords:
CINC-1CINC-2αMCP-1pneumoniasenile

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