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Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
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Associations of plasma hepcidin with mortality risk in patients with coronary artery disease

Xinrui Li1, Ding Ding1, Yuan Zhang2

  • 1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.

Oncotarget
|January 10, 2018
PubMed

Insights

High hepcidin levels predict mortality in acute coronary syndrome (ACS) patients. This finding suggests hepcidin may serve as a valuable biomarker for risk stratification in ACS.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Atherosclerosis Research

Background:

  • Hepcidin, a key regulator of iron metabolism, is implicated in atherosclerosis.
  • The prognostic value of hepcidin in coronary artery disease (CAD) mortality is not well-established.
  • This study investigates hepcidin's association with mortality in CAD patients, with and without acute coronary syndrome (ACS).

Purpose of the Study:

  • To determine the relationship between plasma hepcidin levels and all-cause and cardiovascular disease (CVD) mortality.
  • To assess the predictive value of hepcidin in patients with stable CAD and ACS.

Main Methods:

  • A cohort of 759 ACS patients and 526 stable CAD patients was followed for an average of 4.1 years.
  • Plasma hepcidin levels were measured and correlated with mortality outcomes.
  • Statistical analyses, including multivariable regression and risk reclassification, were performed after adjusting for CVD risk factors and inflammatory markers.

Main Results:

  • Increased plasma hepcidin was significantly associated with higher all-cause and CVD mortality in ACS patients.
  • Multivariable-adjusted hazard ratios demonstrated a dose-response relationship between hepcidin tertiles and mortality.
  • Inclusion of hepcidin improved cardiovascular risk prediction models, showing significant net reclassification improvement.

Conclusions:

  • Plasma hepcidin is a positive predictor of mortality in patients with ACS.
  • Hepcidin emerges as a potential novel biomarker for enhanced risk prediction in ACS patients.
Abstract

Keywords:
cohort studycoronary artery diseasehepcidinmortality

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