Related Experiment Video
Updated: Feb 15, 2026
09:23
Harmonic Nanoparticles for Regenerative Research
Published on: May 1, 2014
12.2K
Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development
1College of Marine Sciences, Ningbo University, Ningbo, Zhejiang, China.
Oncotarget
|January 10, 2018
Summary
Environmental exposure to nanoparticles (NPs) can harm pregnant women and developing fetuses. These NPs disrupt female reproductive organs, oogenesis, and embryonic development, posing significant health risks.
Area of Science:
- Reproductive Toxicology
- Environmental Health
- Nanomedicine
Background:
- Nanoparticle (NP) applications are increasing, leading to greater environmental exposure and health concerns.
- Exposure to NPs during pregnancy can induce maternal toxic stress, affecting reproductive organs.
Purpose of the Study:
- To summarize the toxic effects of various NPs on the female reproductive system, oogenesis, and embryonic development.
- To highlight future research directions and provide guidelines for protecting the female reproductive system from NP toxicity.
Main Methods:
- Review of recent studies on nanoparticle toxicity in reproductive organs.
- Analysis of NP interactions with oocytes and the placental barrier.
- Examination of NP effects on sex hormone levels and fetal development.
Main Results:
- NPs can invade oocyte protective layers and disrupt sex hormone regulation via the hypothalamic-pituitary-gonadal axis.
- NPs crossing the placenta can cause fetal inflammation, apoptosis, genotoxicity, and developmental issues.
- NP toxicity is influenced by factors like size, dosage, shape, charge, material, and surface coating.
Conclusions:
- Nanoparticles pose significant risks to female reproductive health, oogenesis, and embryonic development.
- Further research is needed to understand NP toxicity mechanisms and develop protective strategies.
- This review offers guidelines for mitigating NP risks to the female reproductive system.
Related Concept Videos
02:07Oogenesis
70.2K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
70.2K
01:22Oogenesis
4.2K
Oogenesis, the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is...
4.2K
01:24Disorders of the Female Reproductive System
4.5K
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
4.5K
01:27Reproductive Cloning
32.8K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.8K
01:24Role of Affect in Interpersonal Attraction
240
Affect plays a crucial role in shaping interpersonal evaluations and perceptions. Emotions influence how individuals judge and respond to others, often determining whether interactions are viewed positively or negatively. This effect can manifest directly through interactions with the person in question or indirectly via associations with unrelated emotional experiences.Direct Effects of Affect on AttractionAffect directly influences interpersonal attraction when a person’s behavior...
240
01:29The Influence of Affect on Cognition
307
Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
307