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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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piRNA - Piwi-interacting RNAs02:57

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
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The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
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Related Experiment Video

Updated: Feb 15, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Use of Alu Element Containing Minigenes to Analyze Circular RNAs

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Circular RNAs in thoracic diseases.

Fan Yang1, Ping Zhu1, Jintao Guo1

  • 1Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Journal of Thoracic Disease
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are stable, noncoding RNAs regulating gene expression. Their roles in disease suggest potential as biomarkers for diagnosing and treating thoracic conditions.

Keywords:
Circular RNAs (circRNAs)diagnosisthoracic diseasestreatment

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Related Experiment Videos

Last Updated: Feb 15, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are noncoding RNAs with a unique closed structure.
  • They are widely expressed, conserved, and stable, suggesting significant biological roles.
  • circRNAs function as miRNA sponges, splicing regulators, or even protein-coding sequences.

Purpose of the Study:

  • To review current research on circRNAs.
  • To explore the potential clinical applications of circRNAs in thoracic diseases.

Main Methods:

  • Literature review of circRNA research.
  • Analysis of circRNA functions and disease associations.

Main Results:

  • circRNAs are regulators of gene expression and miRNA activity.
  • circRNA expression is linked to various pathological conditions.
  • circRNA-miRNA networks influence disease pathways.

Conclusions:

  • circRNAs hold promise as diagnostic and therapeutic biomarkers for thoracic diseases.
  • Further research into circRNAs is crucial for disease prevention and treatment strategies.