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The link between spontaneous coronary artery dissection and takotsubo cardiomyopathy: analysis of the published cases

Dario Buccheri1, Giulia Zambelli2

  • 1Interventional Cardiology, San Giovanni di Dio Hospital, Agrigento, Italy.

Journal of Thoracic Disease
|January 10, 2018
PubMed

Insights

Spontaneous coronary artery dissection (SCAD) and takotsubo cardiomyopathy (TTS) are non-atherosclerotic causes of myocardial infarction predominantly affecting women. This review explores their shared pathophysiology, clinical presentation, and existing literature, considering cases with both conditions.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Medical Research

Background:

  • Spontaneous coronary artery dissection (SCAD) and takotsubo cardiomyopathy (TTS) are non-atherosclerotic conditions leading to myocardial infarction.
  • Both SCAD and TTS predominantly affect females and share unclear etiological mechanisms.
  • Both conditions can manifest as acute coronary syndrome.

Purpose of the Study:

  • To explore the shared pathophysiology between SCAD and TTS.
  • To review existing literature and presented cases involving both SCAD and TTS.
  • To deepen the understanding of these two distinct yet related cardiovascular conditions.

Main Methods:

  • Literature review of SCAD and TTS.
  • Analysis of pathophysiological similarities.
  • Case study review of patients presenting with both SCAD and TTS.

Main Results:

  • Identified common features in pathophysiology and clinical presentation between SCAD and TTS.
  • Highlighted the predilection for female patients in both conditions.
  • Underscored the need for further investigation into the exact mechanisms.

Conclusions:

  • SCAD and TTS represent significant non-atherosclerotic causes of myocardial infarction with overlapping characteristics.
  • Further research is warranted to elucidate the precise pathophysiological links and mechanisms.
  • Understanding these connections is crucial for accurate diagnosis and management.

Keywords:
Spontaneous coronary artery disease (SCAD)acute coronary syndrome (ACS)coronary angiographycoronary artery disease (CAD)interventional cardiologyintravascular imagingtakotsubo cardiomyopathy (TTS)

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