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Updated: Feb 15, 2026
08:33
Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells
Published on: April 25, 2014
20.4K
Malignant Epithelial Transformation in Phyllodes Tumor: A Population-Based Case Series.
Ralph L Widya1, Myra F Rodrigues2, Pauline T Truong3
1Radiology, Leiden University Medical Center.
Cureus
|January 10, 2018
Summary
Malignant epithelial transformation in phyllodes tumors (PT) of the breast occurred in 6.0% of cases. Outcomes were favorable for patients with PT and associated carcinoma, indicating good prognosis after treatment.
Area of Science:
- Oncology
- Breast Pathology
- Surgical Pathology
Background:
- Phyllodes tumors (PT) are uncommon fibroepithelial neoplasms of the breast.
- Malignant epithelial transformation within PT is a rare occurrence.
Purpose of the Study:
- To report the clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT.
- To assess the prevalence and prognostic implications of carcinoma in PT.
Main Methods:
- Retrospective analysis of 183 PT cases diagnosed between 1999 and 2014.
- Identification of 11 cases with concomitant in situ or invasive carcinoma.
- Descriptive analysis of patient demographics, tumor characteristics, treatment, and outcomes.
Main Results:
- Prevalence of malignant epithelial transformation in PT was 6.0%.
- Associated carcinomas included ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), and invasive ductal carcinoma (IDC).
- All patients achieved favorable outcomes with no evidence of disease at follow-up.
Conclusions:
- The prevalence of malignant epithelial transformation in PT may be higher than previously reported.
- Favorable outcomes suggest a good prognosis for PT with associated in situ or invasive carcinoma.
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