One-and-a-half syndrome with its spectrum disorders

Area of Science:

• Neurology
• Ophthalmology

Background:

• One-and-a-half syndrome, first described by Fisher in 1967, is a rare neurological condition.
• It is characterized by a specific combination of horizontal eye movement abnormalities.

Purpose of the Study:

• To review rare cases within the one-and-a-half syndrome spectrum disorders.
• To describe the clinical and pathological features of these related syndromes.
• To summarize the nomenclature of these rare conditions.

Main Methods:

• Literature review of rare one-and-a-half syndrome spectrum disorders.
• Analysis of clinical presentations.
• Pathological feature description.
• Nomenclature summarization.

Main Results:

• Detailed review of rare one-and-a-half syndrome spectrum disorders.
• Description of distinct clinical and pathological characteristics for each syndrome.
• Consolidated nomenclature for related rare syndromes.

Conclusions:

• The one-and-a-half syndrome spectrum encompasses a range of rare disorders.
• Understanding their unique features and classification is crucial for diagnosis and research.