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Updated: Feb 15, 2026
09:16
High-resolution Patterning Using Two Modes of Electrohydrodynamic Jet: Drop on Demand and Near-field Electrospinning
Published on: July 10, 2018
10.3K
Engineering of nanoparticle size via electrohydrodynamic jetting
Sahar Rahmani1,2,3, Sumaira Ashraf4, Raimo Hartmann4
1Biointerfaces Institute, University of Michigan Ann Arbor MI 48109.
Bioengineering & Translational Medicine
|January 10, 2018
Summary
Controlling nanoparticle size is key for drug delivery systems. Smaller nanoparticles (174 nm) show higher intralysosomal localization due to faster endosomal uptake, influencing therapeutic efficacy.
Area of Science:
- Nanotechnology
- Materials Science
- Biomedical Engineering
Background:
- Particle size engineering is crucial for effective therapeutic delivery systems.
- Controlling nanoparticle physicochemical properties impacts their biological fate.
Purpose of the Study:
- To explore fabrication methods for size-controlled nanoparticles.
- To investigate nanoparticle fractionation and size-dependent cellular interactions.
Main Methods:
- Fabrication of nanoparticles using charged species and high dielectric constant solvents.
- Fractionation of nanoparticles by size using centrifugation.
- In vitro assessment of nanoparticle uptake and intracellular transport.
Main Results:
- Charged species and solvent properties influence nanoparticle size and distribution.
- Smaller nanoparticles (average 174 nm) exhibited higher intralysosomal localization.
- Increased incubation time enhanced nanoparticle internalization and cellular uptake.
Conclusions:
- A technological approach for producing size-defined nanoparticles was established.
- Nanoparticle size significantly modulates cellular uptake and intracellular fate.
- Future research should explore targeting ligands for enhanced nanoparticle delivery.
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