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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

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ROS-responsive drug delivery systems

Jing Liang1, Bin Liu1,2

  • 1Dept of Chemical and Biomolecular Engineering National University of Singapore 117585 Singapore.

Bioengineering & Translational Medicine
|January 10, 2018
PubMed

Insights

Reactive oxygen species (ROS) are crucial in cell signaling but excess ROS causes oxidative stress and disease. ROS-responsive drug delivery systems (DDSs) offer targeted therapy with reduced side effects.

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Materials Science

Background:

  • Reactive oxygen species (ROS) are vital for cellular signaling and metabolism.
  • Excessive ROS production causes oxidative stress, implicated in diseases like cancer, aging, and inflammation.
  • ROS-responsive drug delivery systems (DDSs) are emerging to address these challenges.

Purpose of the Study:

  • To review the latest advancements in ROS-responsive DDSs.
  • To discuss the design principles of these responsive systems.
  • To explore their diverse biomedical applications.

Main Methods:

  • Literature review of recent research on ROS-responsive DDSs.
  • Analysis of design strategies for controlled drug release.
  • Examination of multifunctional DDS capabilities.

Main Results:

  • ROS-responsive DDSs enable targeted drug release at sites with high ROS levels.
  • These systems enhance therapeutic efficacy and minimize systemic side effects.
  • Multifunctional DDSs offer combined imaging, therapy, and targeting.

Conclusions:

  • ROS-responsive DDSs represent a promising frontier in targeted drug delivery.
  • Advanced designs incorporating multiple stimuli and functionalities are expanding their potential.
  • These systems hold significant promise for treating ROS-associated diseases.
Keywords:
ROS‐responsivechemotherapydrug delivery systemreactive oxygen speciesstimuli‐responsivetheranostics

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