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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

23
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
23
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

22
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
22
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

20
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
20
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

16
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
16
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

20
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
20
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

24
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
24

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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

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ROS-responsive drug delivery systems.

Jing Liang1, Bin Liu1,2

  • 1Dept of Chemical and Biomolecular Engineering National University of Singapore 117585 Singapore.

Bioengineering & Translational Medicine
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Reactive oxygen species (ROS) are crucial in cell signaling but excess ROS causes oxidative stress and disease. ROS-responsive drug delivery systems (DDSs) offer targeted therapy with reduced side effects.

Keywords:
ROS‐responsivechemotherapydrug delivery systemreactive oxygen speciesstimuli‐responsivetheranostics

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Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Materials Science

Background:

  • Reactive oxygen species (ROS) are vital for cellular signaling and metabolism.
  • Excessive ROS production causes oxidative stress, implicated in diseases like cancer, aging, and inflammation.
  • ROS-responsive drug delivery systems (DDSs) are emerging to address these challenges.

Purpose of the Study:

  • To review the latest advancements in ROS-responsive DDSs.
  • To discuss the design principles of these responsive systems.
  • To explore their diverse biomedical applications.

Main Methods:

  • Literature review of recent research on ROS-responsive DDSs.
  • Analysis of design strategies for controlled drug release.
  • Examination of multifunctional DDS capabilities.

Main Results:

  • ROS-responsive DDSs enable targeted drug release at sites with high ROS levels.
  • These systems enhance therapeutic efficacy and minimize systemic side effects.
  • Multifunctional DDSs offer combined imaging, therapy, and targeting.

Conclusions:

  • ROS-responsive DDSs represent a promising frontier in targeted drug delivery.
  • Advanced designs incorporating multiple stimuli and functionalities are expanding their potential.
  • These systems hold significant promise for treating ROS-associated diseases.