Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Current Trends in Nursing I01:28

Current Trends in Nursing I

5.5K
Current trends in nursing include:
5.5K
Current Trends in Nursing II01:30

Current Trends in Nursing II

3.6K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.6K
Trends in Lattice Energy: Ion Size and Charge02:54

Trends in Lattice Energy: Ion Size and Charge

26.8K
An ionic compound is stable because of the electrostatic attraction between its positive and negative ions. The lattice energy of a compound is a measure of the strength of this attraction. The lattice energy (ΔHlattice) of an ionic compound is defined as the energy required to separate one mole of the solid into its component gaseous ions. For the ionic solid sodium chloride, the lattice energy is the enthalpy change of the process:
26.8K
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

6.3K
The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
6.3K
Scalar Product (Dot Product)01:11

Scalar Product (Dot Product)

27.9K
The scalar multiplication of two vectors is known as the scalar or dot product. As the name indicates, the scalar product of two vectors results in a number, that is, a scalar quantity. Scalar products are used to define work and energy relations. For example, the work that a force (a vector) performs on an object while causing its displacement (a vector) is defined as a scalar product of the force vector with the displacement vector.
The scalar product of two vectors is obtained by multiplying...
27.9K
Vector Product (Cross Product)01:17

Vector Product (Cross Product)

28.2K
Vector multiplication of two vectors yields a vector product, with the magnitude equal to the product of the individual vectors multiplied by the sine of the angle between both the vectors and the direction perpendicular to both the individual vectors. As there are always two directions perpendicular to a given plane, one on each side, the direction of the vector product is governed by the right-hand thumb rule.
Consider the cross product of two vectors. Imagine rotating the first vector about...
28.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of Dual Virus Spike Approach to Accelerate Early-Stage Viral Clearance Studies.

Biotechnology and bioengineering·2025
Same author

Unlocking efficiency in column chromatography with packed bed supporting inserts.

Frontiers in bioengineering and biotechnology·2025
Same author

Application of platform process development approaches to the manufacturing of Mabcalinâ„¢ bispecifics.

Journal of biotechnology·2023
Same author

Application of inline variable pathlength technology for rapid determination of dynamic binding capacity in downstream process development of biopharmaceuticals.

Biotechnology progress·2022
Same author

Development of a platform-based approach for the clinical production of HIV gp120 envelope glycoprotein vaccine candidates.

Vaccine·2021
Same author

Modulation of high mannose levels in N-linked glycosylation through cell culture process conditions to increase antibody-dependent cell-mediated cytotoxicity activity for an antibody biosimilar.

Biotechnology progress·2021
Same journal

An ex vivo injury model perfused with whole blood reveals rapid mechanical and transcriptional changes within the spinal cord.

Bioengineering & translational medicine·2026
Same journal

Harnessing nanotechnology: Transforming ocular drug delivery with advanced hydrogel systems.

Bioengineering & translational medicine·2026
Same journal

Open-source bioreactor delivers electrical and perfusion stimulation supporting 3D cardiac engineered tissue maturation.

Bioengineering & translational medicine·2026
Same journal

Engineering human peritoneum in vitro: A novel microfluidic platform for modeling peritoneal physiology and pathophysiology.

Bioengineering & translational medicine·2026
Same journal

Application of hydrogels in 3D tumor microenvironment modeling and drug screening for cervical cancer: A review.

Bioengineering & translational medicine·2026
Same journal

Effects of multi-electrode electrostatic precipitation during intraperitoneal aerosolized drug delivery: Insights from a large animal model.

Bioengineering & translational medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
08:03

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Published on: April 18, 2013

17.8K

Evolving trends in mAb production processes.

Abhinav A Shukla1, Leslie S Wolfe1, Sigma S Mostafa1

  • 1Process Development & Manufacturing KBI Biopharma Inc.Durham NC 27704.

Bioengineering & Translational Medicine
|January 10, 2018
PubMed
Summary
This summary is machine-generated.

Monoclonal antibody (mAb) manufacturing is evolving due to biosimilars and high-titer cell cultures. This drives innovation in bioprocessing, including new expression systems and continuous manufacturing for biologics.

Keywords:
Fc fusion proteinsbiosimilarsbispecific antibodiescontinuous bioprocessinghigh titer cell culturemonoclonal antibodiesnext generation monoclonal antibodiesnonchromatographic separationsplatform processprocess development

More Related Videos

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

9.7K
Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

12.8K

Related Experiment Videos

Last Updated: Feb 15, 2026

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research
08:03

Multi-analyte Biochip MAB Based on All-solid-state Ion-selective Electrodes ASSISE for Physiological Research

Published on: April 18, 2013

17.8K
Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

9.7K
Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER
07:26

Designing Automated, High-throughput, Continuous Cell Growth Experiments Using eVOLVER

Published on: May 19, 2019

12.8K

Area of Science:

  • Biopharmaceutical Manufacturing
  • Bioprocessing Engineering
  • Antibody Therapeutics

Background:

  • Monoclonal antibodies (mAbs) are a leading biopharmaceutical therapeutic class.
  • Robust manufacturing platforms are critical for successful antibody drug development and commercialization.
  • Current mAb production faces pressures from biosimilars and the need for cost-effective, globalized manufacturing.

Purpose of the Study:

  • To discuss the key drivers influencing the evolution of monoclonal antibody (mAb) manufacturing processes.
  • To highlight emerging trends in bioprocessing that address current industry needs.
  • To analyze the impact of these drivers and trends on mAb production strategies.

Main Methods:

  • Review of current trends and drivers in biopharmaceutical manufacturing.
  • Analysis of process platform evolution in response to industry demands.
  • Discussion of alternative expression systems, continuous biomanufacturing, and non-chromatographic separations.

Main Results:

  • Biosimilar market entry necessitates lower cost of goods and globalized manufacturing strategies.
  • High-titer monoclonal antibody (mAb) production in mammalian cell culture is now standard.
  • Significant evolution in process platform approaches and bioprocessing trends are evident.

Conclusions:

  • Key drivers such as biosimilars and high titers are reshaping mAb manufacturing.
  • Emerging bioprocessing trends like continuous manufacturing and alternative expression systems are critical for future antibody production.
  • Adaptation of manufacturing processes is essential for continued success in the biopharmaceutical therapeutics market.