Related Experiment Video
Updated: Feb 15, 2026

Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery
Published on: October 4, 2018
B cell aplasia and hypogammaglobulinemia associated with levetiracetam
Hulya Ozdemir1, Sua Sumer, Hakan Karabagli
1Hulya Ozdemir, Department of Pediatric Immunology and Allergy,, Medical Faculty, Selcuk University,, Alaeddin Keykubat Campus,, 42130 Selcuklu/Konya, Turkey, T: +90 332 2244496, hulyaozdemir1@gmail.com, ORCID: http://orcid.org/0000-0002-0287-5260.
Abstract:
Levetiracetam (LEV) is a second-generation antiepileptic drug approved for the treatment of several types of epilepsy. We report a 45-year-old female who developed hypogammaglobulinemia and B cell aplasia during LEV treatment. The Naranjo probability score for an adverse drug reaction was 6. After LEV discontinuation, the number of B cells gradually increased and reached normal levels within two months. This case suggests that monitoring of immunoglobulin levels and lymphocyte subsets analysis is important in patients treated with LEV, especially in cases of prolonged infections.
Similar Cases Published:
1.
Related Concept Videos
What are Cells?
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
What are Cells?
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
What is Cell Signaling?
Chemistry of the Cell
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
Concentration Cells
Consider the following voltaic cell:
Cell Size
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...

