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Updated: Feb 15, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
Nucleophilic fluorination facilitated by a CsF-CaF2 packed bed reactor in continuous flow
1Department of Engineering, Center for Carbon Dioxide Activation (CADIAC), Interdisciplinary Nanoscience Centre (iNANO), Aarhus University, Hangøvej 2, DK-8200 Aarhus N, Denmark. Lindhardt@eng.au.dk.
Abstract:
A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations.
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