Related Experiment Video
Updated: Feb 15, 2026

Laser Micromachining for Polymer Surface Topography Design
Published on: September 19, 2025
The effect of ordered and partially ordered surface topography on bone cell responses: a review
1Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, Victoria 3000, Australia. ma.qian@rmit.edu.au.
Abstract:
Implant surfaces play important roles in regulating protein adsorption and determining subsequent cell responses, including cell attachment, proliferation, migration and differentiation. With rapid developments in micro- and nano-fabrication methods and additive manufacturing (3D printing) technologies, precisely controlled patterns such as partially ordered or ordered patterns can now be generated on bone implant surfaces, rather than restricted to randomly roughened surfaces. Over the last two decades, much effort has been dedicated to manipulating cell responses through surface topographical modifications. This review discusses the recent developments and understanding of surface topography in prompting or enhancing desired cell responses, particularly the roles of ordered and partially ordered surface topography under in vitro conditions. In addition, the challenges to translate research findings into implant applications are addressed.
Related Concept Videos
Response Surface Methodology
The process of RSM involves several key steps:
Methods of Obtaining Topography
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Cell-surface Signaling
Partial Fractions

