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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
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Fosfomycin Susceptibility in Urinary Tract Enterobacteriaceae
Bhargav Patel1, Kinjal Patel2, Anjali Shetty3
1Consultant Microbiologist, HCG Hospital, Ahmedabad, Gujarat.
The Journal of the Association of Physicians of India
|January 10, 2018
Summary
Fosfomycin shows significant in-vitro activity against multi-drug resistant urinary tract pathogens, including ESBL and CRE strains. This suggests fosfomycin is a valuable option for treating challenging urinary tract infections.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Rising antibiotic resistance in uropathogens (ESBLs, AmpC, CRE) complicates Urinary Tract Infection (UTI) treatment.
- Fosfomycin, an older antibiotic, is regaining interest due to its unique structure and lack of cross-resistance with other agents.
Purpose of the Study:
- To evaluate the in-vitro activity of fosfomycin against urinary tract Enterobacteriaceae.
- To assess fosfomycin's efficacy against multidrug-resistant uropathogens.
Main Methods:
- Collected and identified 72 uropathogen isolates using biochemical tests.
- Performed antimicrobial susceptibility testing with Vitek 2 automated system.
- Determined fosfomycin susceptibility using E-test, interpreting results against CLSI criteria for E. coli.
Main Results:
- 79.16% of isolates were susceptible to fosfomycin.
- Susceptibility was high in ESBL-producing (92.00%) and CRE (72.34%) enterobacteriaceae.
- One CRE isolate developed resistance during treatment.
Conclusions:
- Fosfomycin demonstrated considerable in-vitro activity against multidrug-resistant Enterobacteriaceae.
- Fosfomycin can be considered a useful addition to the antibiotic arsenal for treating UTIs.
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