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Association between bullous pemphigoid and malignancy: A meta-analysis.
Richard J Lucariello1, Salvadore E Villablanca2, José M Mascaró3
1School of Medicine, New York Medical College, Valhalla, New York, USA.
This meta-analysis found an 11% malignancy rate in bullous pemphigoid patients, higher than controls. The risk was lower in Asian populations compared to European ones.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- Bullous pemphigoid (BP) is an autoimmune blistering disease.
- Previous studies suggest a potential link between BP and increased malignancy risk, but findings are inconsistent.
Purpose of the Study:
- To conduct a meta-analysis to investigate the association between bullous pemphigoid and the risk of malignancy.
Main Methods:
- A systematic search of PubMed and Embase databases was performed.
- Included studies compared malignancy rates in patients with bullous pemphigoid to matched controls or general populations.
- Data from 16 studies involving 9398 bullous pemphigoid cases were analyzed.
Main Results:
- The overall malignancy rate in bullous pemphigoid patients was 11% (95% CI: 9-14%).
- Malignancy rates were 9% in Asian populations and 13% in European populations, with a significantly lower risk in Asians (OR=0.69).
- Bullous pemphigoid patients showed a significantly higher risk of malignancy compared to matched controls (OR=2.08).
Conclusions:
- Bullous pemphigoid is associated with an elevated risk of malignancy.
- The risk appears to be lower in Asian populations compared to European populations.
- Further research controlling for confounding variables is warranted.
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