Related Experiment Video
Updated: Feb 15, 2026
10:03
Characterization of Electrode Materials for Lithium Ion and Sodium Ion Batteries Using Synchrotron Radiation Techniques
Published on: November 11, 2013
26.1K
Water equivalent PRESAGE® for synchrotron radiation therapy dosimetry
Frank M Gagliardi1,2, Liam Day3, Christopher M Poole3
1Alfred Health Radiation Oncology, The Alfred, Melbourne, Vic, 3004, Australia.
Medical Physics
|January 10, 2018
Summary
A new water equivalent PRESAGE® dosimeter accurately measures 3D dosimetry for synchrotron radiation therapy, validating treatment planning systems. This advancement aids in precise radiation delivery for cancer treatment.
Area of Science:
- Medical Physics
- Radiation Oncology
- Dosimetry
Background:
- Synchrotron Radiation Therapy (SRT) is an emerging cancer treatment modality requiring precise dosimetry.
- Current patient treatment planning systems (TPS) rely on simulated synchrotron x-ray beam data.
- A need exists for a dosimeter capable of accurate 3D dosimetry across SRT energy ranges.
Purpose of the Study:
- To investigate a water-equivalent PRESAGE® dosimeter for 3D dosimetry.
- To evaluate its performance over an energy range suitable for synchrotron x-ray beams.
- To validate its use in conjunction with patient treatment planning systems.
Main Methods:
- Fabricated water-equivalent PRESAGE® dosimeters with a radiological effective atomic number similar to water.
- Irradiated dosimeters across a 10 keV to 10 MeV energy range.
- Performed 3D dosimetry using optical CT (OCT) scanning and compared results with ion chamber measurements and Monte Carlo (MC) simulations.
Main Results:
- PRESAGE® Percentage Depth Dose (PDD) profiles agreed within 2% with ion chamber measurements and MC calculations.
- Good agreement was observed with MC models for depths below 5 mm, where ion chamber data are unavailable.
- While OCT spatial resolution limited penumbra measurement, PRESAGE® successfully verified MC dose profile characteristics.
Conclusions:
- The radiological response of the water-equivalent PRESAGE® dosimeter is validated for SRT x-ray beam energies.
- The dosimeter can independently verify dose distributions generated by MC models.
- This validates PRESAGE® as a tool for accurate 3D dosimetry in SRT applications.
More Related Videos
Related Concept Videos
02:59Biological Effects of Radiation
18.1K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.1K
01:26Pharmaceutical Equivalents
209
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
209
01:19Equivalent Capacitance
2.2K
Multiple capacitors can be connected in a circuit in series or parallel configuration. When the capacitor combination is connected to a battery, the potential drop across each capacitor and the magnitude of charge stored in the individual capacitor depends on the type of the connection. The capacitor combination is replaced by a single equivalent capacitor that stores the same amount of charge as the combination for a given potential difference.
The following strategies are adopted to calculate...
The following strategies are adopted to calculate...
2.2K
01:19Equivalent Capacitance
729
From the study of resistive circuits, it is understood that employing a series-parallel combination serves as an effective strategy for simplifying circuits. Capacitors can be arranged within a circuit in one of two ways: a series configuration or a parallel configuration. The way these capacitors are connected to a battery will influence both the potential drop across each individual capacitor and the size of the charge that each capacitor can store. This is determined by the specific type of...
729
01:18Thévenin Equivalent Circuits
701
The household power distribution system, encompassing distribution lines and transformers, serves as the primary network. Electrical appliances within a household can be represented as load impedance. To simplify this intricate distribution system, Thévenin's theorem can be applied to create a Thévenin equivalent circuit. If an AC circuit is partitioned into two parts (circuit A and circuit B), connected by a single pair of terminals as shown in Figure 1.
701
01:18Principle of Equivalence
2.6K
According to Albert Einstein (1897-1955), free-falling and feeling weightless are intrinsically linked. If a person were in free-fall under gravity, for example, diving towards the Earth from an airplane, they would feel completely weightless. Similarly, a person descending in a lift may feel partially weightless. Broadly speaking, it is assumed that an object in a uniform gravitational field and an object undergoing constant acceleration in the absence of gravity are under the same...
2.6K