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High frequency of MGUS in DSP.
Alon Abraham1, Carolina Barnett2, Hans D Katzberg2
1Neuromuscular Service of the Department of Neurology, Tel Aviv Sourasky Medical Center, the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Muscle & Nerve
|January 10, 2018
Summary
Monoclonal gammopathy is frequently observed in diabetic sensorimotor polyneuropathy (DSP), particularly in type 2 diabetes mellitus. Frequencies were 14% in type 1 and 21% in type 2 diabetes patients with DSP.
Area of Science:
- Neurology
- Endocrinology
- Immunology
Background:
- Monoclonal gammopathy is linked to various polyneuropathies.
- Diabetic sensorimotor polyneuropathy (DSP) is a common complication of diabetes mellitus.
Purpose of the Study:
- To determine the frequency of monoclonal gammopathy in patients with DSP.
- To characterize monoclonal gammopathy in type 1 and type 2 diabetes mellitus (DM).
Main Methods:
- Patients with type 1 DM, type 2 DM, and controls were evaluated.
- Monoclonal gammopathy was assessed in all participants.
Main Results:
- Monoclonal gammopathy was absent in controls (0%).
- Frequencies were 8% in type 1 DM and 15% in type 2 DM.
- In DSP patients, frequencies were 14% (DM 1) and 21% (DM 2), with IgM and IgG being most common.
Conclusions:
- DSP is associated with a high incidence of monoclonal gammopathy.
- The characteristics of monoclonal gammopathy differ between type 1 and type 2 diabetes.
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