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Updated: Feb 15, 2026
05:26
Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
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Comparative histomorphological study of endometrium in mares.
M Herrera1,2, J M Herrera2, S Cantatore1,3
1Facultad de Ciencias Veterinarias, Laboratorio de Clínica y Reproducción Equina, CIVETAN, UNICEN, Tandil, Argentina.
Anatomia, Histologia, Embryologia
|January 10, 2018
Summary
Mare susceptibility to endometritis is linked to specific endometrial characteristics. Susceptible mares exhibit greater epithelial height and glandular development during oestrus, impacting fertility.
Area of Science:
- Reproductive Biology
- Veterinary Medicine
- Equine Science
Background:
- Persistent endometritis causes subfertility in mares (Equus ferus caballus).
- Mares are classified as susceptible or resistant to endometritis based on intrauterine fluid clearance.
- Endometrial biopsy and histomorphometry are key diagnostic tools for assessing fertility-compromising lesions.
Purpose of the Study:
- To compare endometrial histomorphometry in mares susceptible (SM) versus resistant (RM) to endometritis during oestrus.
- To investigate potential correlations between endometrial structural characteristics and endometritis susceptibility.
Main Methods:
- Endometrial biopsies were collected from 24 mares during oestrus.
- Histomorphometric analysis involved routine Haematoxylin-Eosin staining.
- Evaluated variables included epithelial height, glandular diameters, and gland density.
Main Results:
- Susceptible mares (SM) showed greater lining epithelial height (15.9 μm) than resistant mares (RM) (13.3 μm).
- Glandular epithelia height was greater in SM (15.0 μm) vs. RM (13.0 μm).
- SM had larger glandular perpendicular diameters (51.3 μm vs. 44.8 μm) and higher gland density (24.8 glands/field vs. 20.5 glands/field).
Conclusions:
- Histomorphometric differences in endometrial structure are associated with endometritis susceptibility in mares.
- Increased epithelial height, glandular density, and gland development during oestrus correlate with higher endometritis susceptibility.
- These findings offer insights into the physiological basis of equine endometritis and subfertility.
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