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Isotretinoin-induced acne fulminans without systemic symptoms with concurrent exuberant granulation tissue
Alvin W Li1, Richard J Antaya2,3
1School of Medicine, Yale University, New Haven, CT, USA.
Abstract:
Acne fulminans is a severe form of acne characterized by painful, inflammatory nodules that progress into ulcers and concurrent systemic symptoms. Treatment of acne with isotretinoin can precipitate a syndrome called isotretinoin-induced acne fulminans without systemic symptoms. An exuberant granulation tissue response, another known adverse event associated with isotretinoin, can occur concurrently, inhibiting wound repair and complicating treatment. We report a case of isotretinoin-induced acne fulminans without systemic symptoms with exuberant granulation tissue response that was treated successfully with topical clobetasol ointment.
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