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Related Experiment Videos

Cow's milk allergic children-Can component-resolved diagnostics predict duration and severity?

Thomas Houmann Petersen1, Charlotte Gotthard Mortz1, Carsten Bindslev-Jensen1

  • 1Department of Dermatology & Allergy Center, Odense Research Center for Anaphylaxis (ORCA), Odense University Hospital, Odense, Denmark.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|January 10, 2018
PubMed
Summary

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Component-resolved diagnostics (CRD) correlate with cow's milk allergy (CMA) severity and persistence. High CRD levels indicate a higher risk of long-lasting CMA, but oral food challenges remain essential for diagnosis.

Area of Science:

  • Pediatric Allergy and Immunology
  • Diagnostic Immunology

Background:

  • Cow's milk allergy (CMA) affects approximately 2% of children.
  • Component-resolved diagnostics (CRD) offer detailed insights into specific allergen sensitization.

Purpose of the Study:

  • To correlate CRD levels with oral food challenge outcomes in children suspected of CMA.
  • To assess if serial CRD measurements can differentiate persistent CMA from developing tolerance.

Main Methods:

  • Retrospective analysis of 78 children with suspected CMA over 13 years.
  • Collection of oral food challenge data (threshold, severity) and sensitization markers (s-IgE, SPT).
  • Regular re-evaluation of allergic children with sensitization data and repeat challenges.

Main Results:

Keywords:
anaphylaxischallenge testscomponent-resolved diagnosticscow's milkfood allergy

Related Experiment Videos

  • Persistent CMA cases showed significantly larger SPT wheal sizes and higher s-IgE to milk and CRD at inclusion.
  • SPT wheal size was a key differentiator between persistent CMA and outgrowing CMA.
  • A correlation was observed between s-IgE to cow's milk/casein and allergic reaction severity.

Conclusions:

  • Oral food challenges are indispensable for diagnosing CMA and cannot be substituted by s-IgE or SPT alone.
  • Elevated milk component and s-IgE levels are associated with an increased risk of persistent CMA.