Related Experiment Video

Updated: Feb 15, 2026

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.0K

Wheezing and infantile colic are associated with neonatal antibiotic treatment

Berthe C Oosterloo1, Ruurd M van Elburg1,2, Nicole B Rutten3

  • 1Academic Medical Center, Emma Children's Hospital, Amsterdam, the Netherlands.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|January 10, 2018
PubMed

Insights

Early antibiotic use in newborns is linked to higher risks of infantile colics and wheezing. This suggests caution with antibiotic prescriptions for infants not confirmed to have infections.

Area of Science:

  • Neonatal medicine
  • Pediatric allergy
  • Microbiome research

Background:

  • Previous cohort studies suggest a link between early-life antibiotic exposure and increased atopy risk.
  • The study investigates if antibiotic treatment within the first week of life elevates the risk of atopic and non-atopic conditions in infants.

Purpose of the Study:

  • To determine the association between early-life antibiotic exposure and the incidence of atopic and non-atopic disorders in the first year of life.
  • To evaluate the impact of neonatal antibiotic treatment on infant health outcomes, including allergic sensitization and common infant ailments.

Main Methods:

  • Prospective observational birth cohort study (INCA study) involving 436 term infants followed for one year.
  • 151 neonates received broad-spectrum antibiotics (AB+), compared to 285 untreated controls (AB-).
  • Daily symptom recording by parents, physician diagnoses, and blood sample analysis at one year were utilized.

Main Results:

  • Higher incidence of wheezing in the first year for the antibiotic-exposed group (41.0% vs 30.5%).
  • Infantile colics were more prevalent in the AB+ group (21.9% vs 14.4%), with antibiotic treatment identified as an independent risk factor.
  • A trend towards higher allergic sensitization was observed in the AB+ group (aOR 3.26).

Conclusions:

  • Antibiotic treatment during the first week of life is associated with an increased risk of wheezing and infantile colics.
  • Findings support the cautious use of antibiotics in neonates, advocating for early cessation in cases without confirmed or probable infection.
Abstract

Keywords:
antibioticsatopyeczemainfantinfantile colicneonatesensitizationwheezing

More Related Videos

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment09:25

Examination of Host Phenotypes in Gambusia affinis Following Antibiotic Treatment

Published on: February 22, 2017

8.0K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.4K

Related Concept Videos

Antibiotic Selection00:57

Antibiotic Selection

Overview
60.3K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
987