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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the

Noureldin Saleh1, Oliver Hucke2, Gert Kramer3

  • 1Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Institute of Medical Physics and Biophysics, Charitéplatz 1, 10117, Berlin, Germany.

Angewandte Chemie (International Ed. in English)
|January 10, 2018
PubMed

Keywords:
G-protein-coupled receptorsallosterycannabinoid receptorsmetadynamics

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