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Published on: September 16, 2022
Non-immediate heparin and heparinoid cutaneous allergic reactions: a role for fondaparinux
Elina Tan1, Grace Thompson1,2, Charlotta Ekstrom1
1Department of Clinical Immunology, Sir Charles Gairdner Hospital, QEII Medical Centre, Perth, Western Australia, Australia.
Abstract:
Non-immediate allergic cutaneous reactions to heparins have been increasingly reported, typically manifesting as large, eczematous plaques at sites of subcutaneous injection. Patients may demonstrate cross-reactivity between unfractionated heparin, low molecular weight heparin and semi-synthetic heparinoids, making finding an alternative difficult. Fondaparinux has been identified as a useful alternative in such patients; here we present the first two documented cases in Australia and a literature review.
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